Pharmaceutical Organic Chemistry 2

Unit 1

Benzene and its derivatives

  • Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
  • Reactions of benzene - nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
  • Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
  • Structure and uses of DDT, Saccharin, BHC and Chloramine


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Unit 2

Phenol* - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

Aromatic Amines* - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

Aromatic Acids* - Acidity, effect of substituents on acidity and important reactions of benzoic acid.



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Unit 3

Fats and Oils

  • Fatty acids - reactions.
  • Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
  • Analytical constants - Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value - significance and principle involved in their determination.


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Unit 4

Polynuclear hydrocarbons:

  • Synthesis, reactions
  • Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives


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Unit 5

Cyclo alkanes*

Stabilities - Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only



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