Pharmaceutical Organic Chemistry 2 - Unit 1

Syllabus

Benzene and its derivatives

• Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
• Reactions of benzene - nitration, sulphonation, halogenationreactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.
• Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction
• Structure and uses of DDT, Saccharin, BHC and Chloramine

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