Medicinal Chemistry 1 - Unit 1

Syllabus

Introduction to Medicinal Chemistry

History and development of medicinal chemistry

Physicochemical properties in relation to biological action

Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism

Drug metabolism

Drug metabolism principles- Phase I and Phase II

Factors affecting drug metabolism including stereo chemical aspects.

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